Work

O-GlcNAcylation in the osteoblast lineage—boosting the complexity of Wnt-stimulated bone formation

Year: 2024

Type: article

Abstract: Although differentiation and activity of bone-forming osteoblasts are regulated at various levels, there is ample evidence that components of the Wnt signaling pathway play a dominant role in bone mass acquisition. Moreover, a neutralizing antibody blocking the Wnt signaling inhibitor sclerostin has recently been established as a novel osteoanabolic treatment option for osteoporotic patients. Importantly, however, the molecular mechanisms explaining the osteogenic influence of Wnt molecules are still not fully clarified. In this issue of EMBO Reports, You and co-workers show that O-GlcNAcylation is required for the osteoanabolic effect of Wnt stimulation, in vitro and in vivo (You et al, 2024). The molecular mechanisms explaining the osteogenic influence of Wnt molecules are still not fully clarified. A study in this issue shows that O-GlcNAcylation is required for the osteoanabolic effects of Wnt stimulation.

Source: EMBO Reports

DOI: 10.1038/s44319-024-00242-2

Authors: Sandra Pohl, Thorsten Schinke

Institution: University Medical Center Hamburg-Eppendorf

Language: English

Topic: Bone Metabolism and Diseases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,890