Work

Molecular and cellular contributors of Rheumatoid Arthritis

Year: 2024

Type: article

Abstract: Rheumatoid arthritis (RA) is a chronic immune-mediated condition affecting about 1% of the world population. Persistent synovial inflammation (synovitis) triggers the hyperplastic transformation of the synovium which eventually destroys juxta-articular bones and articular cartilage. As the disease progresses, RA patients may present systemic and extra-articular manifestations. Particularly, RA patients are at an increased risk of developing cardiovascular events and mortality as compared to individuals without RA. Recent advances in understanding the molecular and cellular mechanisms of RA led to the development of disease-modifying drugs and reliable assessment tools that have significantly improved the management of RA. This review focuses on the current understanding of RA pathogenesis and treatment strategies.

Source: International Journal of Drug Discovery and Pharmacology

DOI: 10.53941/ijddp.2024.100018

Authors: Qingxin Bang, Weihua Song, Xiaomeng Wang

Institutions: National University of Singapore, Duke-NUS Medical School, Agency for Science, Technology and Research, Singapore Eye Research Institute, Institute of Molecular and Cell Biology

Language: English

Topic: Rheumatoid Arthritis Research and Therapies

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Duke-NUS Medical School, Medical Research Council, National Medical Research Council