Editorial: Immune system mechanisms impacting the onset of epilepsy and spontaneous seizures
Year: 2024
Type: editorial
Abstract: Epilepsy, a chronic neurological condition affecting more than 50 million people worldwide (in the U.S. alone almost 3 million Americans), is characterized by spontaneous recurrent seizures and associated with cognitive decline and behavioral comorbidities (WHO 2024; CDC 2024). Despite the major advances made in therapeutics, more than 30% of epilepsy patients suffer from poor control of seizures throughout life (Kalilani et al. 2018). Most of existing drugs are designed to treat the symptoms, but do not prevent epilepsy in people at risk nor modify the disease progression (Galanopoulou et al. 2021;Chen et al. 2018). The development of epilepsy, or epileptogenesis, is a gradual process (Pitkänen et al. 2015); therefore, a better understanding of the underlying pathological processes might lead to identification of more effective targeted therapies or novel avenues to reduce or prevent seizures. Experimental and human evidence builds a solid foundation of a direct link between epileptogenesis and inflammation (Vezzani et al. 2023;Dingledine et al. 2024). This Research Topic provides new insights into the inflammatory and immune mechanisms that might contribute to the onset of epilepsy and spontaneous seizure occurrence.The activation of the complement system has been reported to occur in experimental models of status epilepticus (SE) and human temporal lobe epilepsy (TLE). In previous studies complement C3 levels persisted elevated after SE or at the chronic stage of TLE, correlating with seizure severity and cognitive deficits (Aronica et We are sincerely grateful to all the authors that contributed to this Research Topic. 95
Institutions: Yale University, University of Arizona, Stanford University
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,295
Award: G223639869
OpenAlex ID: W4402422247