Assessment of (EZH2) expression, digital image analysis of CD8+ lymphocytes, and Automated nuclear morphometry in renal cell carcinoma
Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: The enhancer of zeste homolog-2 is overexpressed in many human cancers. High CD8+ T cell density was associated with favorable prognosis in various tumors, but this isn’t true for all cancers. Nuclear grading of RCC is an important prognostic factor but it’s subjective. Automated nuclear morphometry is more accurate. Aim: Evaluation of EZH2 expression, CD8+ density, and nuclear morphometry in RCC. Methods: In this retrospective study, IHC staining of EZH2 and CD8+ was done and assessed for each RCC case. CD8+ density was calculated. Quantitative nuclear morphometry was done by automated image analysis. Results: EZH2 expression showed a highly significant relation with histologic grade(P=0.002), tumor extent(P=0.012), and AJCC stage(P=0.004)& showed a significant relation with nodal metastasis (P=0.033), and distant metastasis(P=0.044). A highly significant relation between CD8+ density and histologic types(P=0.0001), histologic grade(P
Source: Benha Medical Journal
Institution: Benha University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4402443579