Effect of Sitagliptin Versus Glibenclamide on Glycemic Markers and Lipid Profile in a Tertiary Care Hospital, Telangana.
Year: 2024
Type: article
Abstract: Background: Diabetes mellitus is causing long-term problems, namely cardiovascular disorders. This study aimed to examine the impact of Sitagliptin and Glibenclamide on glycemic indicators and lipid prole. Methods: This research study, was carried out on Type 2 diabetes mellitus patients at a tertiary care hospital in Telangana. Two study groups were allocated as Group A – Glibenclamide group (n=30) and Group B - Sitagliptin group (n=30), respectively. Patients were enrolled following inclusion and exclusion criteria. Before the study ethical letter was acquired. SPSS software was used to evaluate the collected data, and a p value of < 0.001* was considered signicant. Results: In this study, Group A had a mean age of 47.3 years and Group B 48.01 years. Group A had a little lower BMI (27.61) than Group B (28.12). The HbA1c percentage in Group A (7.82) was higher than in Group B (7.51). Group A (130.09) had greater LDL than Group B (127.34). Group A (42.72) had somewhat higher HDL than Group B (41.89). Triglycerides were lower in Group A (189.0) than in Group B (210.00). Group A had lower total cholesterol (212.46) than Group B (217.67). The assessed characteristics of the research participants showed a statistically signicant (p=0.001*) BMI change of 0.51 between Groups A and B. Triglycerides (TAGs) levels differed across research groups (p=0.001*). Conclusions: Sitagliptin is a favorable choice for diabetic people with cardiovascular diseases since it can improve inammation and lipid prole. The study ndings offer proof of the favorable inuence of Sitagliptin in mitigating cardiovascular risks among persons diagnosed with type 2 diabetes, with its advantages in regulating insulin-glucose levels.
Institution: Shadan Hospital and Institute of Medical Sciences
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4402448519