Work

How to take down the terminator

Year: 2024

Type: article

Abstract: In bacteria, production of aberrant RNAs and transcription of foreign genes, including those on phages, are readily terminated by a hexameric ATPase, Rho. However, to make necessary transcripts, particularly during stress, bacteria depend on mechanisms to temper Rho activity. Similarly, phages have evolved diverse Rho-inhibitory mechanisms to enable the expression of their own genomes. In recent years, the structural bases of many such anti-termination mechanisms have been elucidated.

Source: BIOspektrum

DOI: 10.1007/s12268-024-2283-x

Authors: Nelly Said, Irina Artsimovitch, Markus C. Wahl

Institutions: Freie Universität Berlin, The Ohio State University, Helmholtz-Zentrum Berlin für Materialien und Energie

Language: English

Topic: Bacterial Genetics and Biotechnology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,090

OpenAlex ID: W4402450275