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An Unusual Case of Metronidazole-Induced Encephalopathy in a Patient with Hereditary Hemorrhagic Telangiectasia

Year: 2024

Type: article

Abstract: Metronidazole-induced encephalopathy (MIE) is a rare toxic encephalopathy. We describe a reversible MIE case in a patient with hereditary hemorrhagic telangiectasia (HHT), treated with metronidazole for brain abscess, who developed dizziness, weakness, dysarthria, and severe dysmetria. His Magnetic Resonance Imaging (MRI) brain revealed bilateral, symmetric lesions in bilateral symmetrical regions of increased intensity in the medullary olives, cerebellar dentate nuclei, and the dorsal pons, all characteristic of MIE. Upon metronidazole discontinuation, the patient experienced significant symptom improvement, with subsequent MRI showing resolution of the lesions.

Source: Journal of Community Hospital Internal Medicine Perspectives

DOI: 10.55729/2000-9666.1398

Authors: Tina H. Dao, Kinza Khan, Christopher D. Jackson

Institution: University of Tennessee Health Science Center

Language: English

Topic: Infectious Encephalopathies and Encephalitis

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $500