Year: 2024
Type: article
Abstract: The majority of mitochondrial proteins are nuclear-encoded and translated in the cytosol with an amino-terminal targeting signal called a presequence. Mitochondrial presequences are able to form amphiphilic α-helices with a positively charged and a hydrophobic side. The essential presequence translocase subunit Tim17 forms a cavity exposed to the bilayer, which harbors a negatively charged patch to initiate the translocation of positively charged presequences across the inner membrane.
Source: BIOspektrum
Institutions: University of Freiburg, Saarland University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,090
OpenAlex ID: W4402461880