Work

Unter Kontrolle – wie ORMDL-Proteine den Sphingolipidhaushalt steuern

Year: 2024

Type: article

Abstract: Sphingolipids are essential components of eukaryotic cell membranes. They typically increase the rigidity of membranes and stabilize membrane-embedded proteins. Yet, they also function as signaling molecules, and some biosynthetic intermediates are toxic at high concentrations, necessitating a tight control of cellular sphingolipid synthesis. We will discuss evolutionarily common regulatory principles, which – upon failure – can lead to devastating neurodegenerative disease in humans.

Source: BIOspektrum

DOI: 10.1007/s12268-024-2257-z

Authors: Niklas Schomisch, Oliver Schmidt

Institutions: Innsbruck Medical University, Universität Innsbruck

Language: English

Topic: Sphingolipid Metabolism and Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,090