Work

Thermal optimization of ivermectin in supercritical carbon dioxide and ethanol to produce nano medicine

Year: 2024

Type: article

Abstract: The solubility of ivermectin in high pressure carbon dioxide (CO 2 ) at 338, 328, 318, and 308 K temperatures was investigated with and without an ethanol. Several methods were employed to model the data obtained from the experiments. ivermectin exhibited solubility values ranging from 0.130 × 10 −5 to 1.760 × 10 −4 in the binary system and 1.880 × 10 −5 to 1.237 × 10 −4 in the ternary system. The outcome indicated that the addition of ethanol significantly increased the mole fraction of ivermectin in CO 2 . The highest impact of ivermectin solubility was found in the ivermectin -Ethanol- CO 2 system at 338 K and 12 MPa, which was about 14.35 times greater than binary system under the same conditions. The models proposed by Jouyban et al. and Sodeifian-Sajadian models showed the best correlation with average absolute relative deviation (AARD%) and Akaike information criterion (AICc) for binary and ternary approaches, respectively. The results confirmed that rapid expansion supercritical solution (RESS) and gas antisolvent (GAS) method can be apply for producing nanoparticles at the suitable ranges of the drug solubility.

Source: Case Studies in Thermal Engineering

DOI: 10.1016/j.csite.2024.105098

Authors: Reem M. Gahtani, Umme Hani, Farhat Fatima, Tariq Nadeem, Riyaz Ali Osmani

Institutions: King Khalid University, Prince Sattam Bin Abdulaziz University, University of the Punjab, JSS Academy of Higher Education and Research, JSS College of Pharmacy

Language: English

Topic: Phase Equilibria and Thermodynamics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,210

Funder: Deanship of Scientific Research, King Khalid University