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Figure 5 from Targeting TREX1 Induces Innate Immune Response in Drug-Resistant Small-Cell Lung Cancer

Year: 2024
Type: other
Abstract: TREX1 expression is induced in posttreated human SCLC tumors. A, IF staining of CK + EpCAM (green), TREX1 (red) protein in patient 25 and patient 6 SCLC tumors are shown, pre- and post-chemotherapy treatment. B, TREX1 IF intensity in 10 patients is compared between pre- and post-chemotherapy treatment. C, TREX1 IHC intensity in a paired PDX tumor is compared between pre- and post-chemotherapy treatment. Scale bar, 100 μm. Data represent mean ± SEM. ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001 by paired Student t test (B).
DOI: 10.1158/2767-9764.27004134.v1
Authors: Takahiko Murayama, Navin R. Mahadevan, Catherine B. Meador, Elena V. Ivanova, Yuqiao Pan, Erik H. Knelson, Tetsuo Tani, Jun Nakayama, Xueying Ma, Tran C. Thai, Yin P. Hung, William Kim, Hideo Watanabe, Kathy Q. Cai, Aaron N. Hata, Cloud P. Paweletz, David A. Barbie, Israel Cañadas
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: gold
OpenAlex ID: W4402486793
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