Synthesis and characterization of some Metal ions complexes with mixed ligand of azo dye and Metformin and evaluation of its effectiveness on the growth of some pathogenic bacteria clinically isolated and study of its Toxicity on normal and cancerous Hepatocytes
Year: 2024
Type: article
Abstract: Four metal compounds mixed ligand of azo dye ligand (L) and metformin.(Met) were produced at aquatic ethanol for (1:1:1) (M:L:Met). The prepared compounds were specified with employed atomic absorption flame, FT.IR and UV-Vis spectrum manners as well as conductivity mensuration. These compounds were evaluated according to the acquired datum in which octahedral geometries in fully prepared complexes were proposed. Also in this research was studied represented examining the antibacterial and antifungal impact of the azo dye ligand (L), metformin.(Met) and (Co, Ni, Cu and Cd complexes) on four types of pathogenic, clinically isolated bacteria that are resistant to antibiotic, like Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia, and fungi Candida albicans from human in Iraq. The results of the sensitivity test showed the effectiveness of these compounds at a very low condensation of (10-3) in inhibiting the isolated bacteria. On the other hand, cytotoxic effects of the ligand, Met and mix ligand complexes showed anticancer activity on HepG2 cells in a serial condensation 15.6, 31, 62, 125, 250, 500µg/ml. As the effectiveness of the compounds increases with increasing their condensation, the most effective toxicant on hepatic cancer cells is Met and cd complex and with a rate of 68.5 and 68.3% respectively.
Source: Heliyon
Institutions: University of Baghdad, University of Anbar
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,100
Funder: University of Baghdad
OpenAlex ID: W4402489662