Work

HIV-Associated Immune Dysfunction and Hematological Abnormalities: A Detailed Examination of Pathophysiology and Clinical Implications

Year: 2024

Type: article

Abstract: Human Immunodeficiency Virus (HIV) exerts profound effects on both the immune and hematological systems, leading to a range of complications that significantly influence patient outcomes and quality of life. This review examines the intricate interplay between HIV infection, immune system dysfunction, and hematological abnormalities. We detail the mechanisms underlying these complications, including the direct impact of HIV on CD4+ T lymphocytes, the persistent immune activation observed despite antiretroviral therapy (ART), and the diverse etiologies of HIV- associated anemia, thrombocytopenia, and leukopenia. Additionally, we address the clinical implications of these issues, emphasizing their role in disease progression and the current therapeutic approaches. This review highlights the imperative for continued research and the advancement of integrated care strategies to enhance long-term outcomes for individuals living with HIV.

Source: International Journal of Innovative Science and Research Technology (IJISRT)

DOI: 10.38124/ijisrt/ijisrt24aug813

Authors: Zakaria EL KODMIRI, Bouchra Ghazi, Abdelati Ouamani, Maryame Ahnach

Institutions: Université Mohammed VI des Sciences et de la Santé, Hôpital Universitaire International Cheikh Khalifa, Instituts Supérieurs des Professions Infirmières et Techniques de Santé

Language: English

Topic: HIV Research and Treatment

Subfield: Virology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402494741