Work

Synthesis and Characterization of Triazine Derivatives as Important Heterocyclic Compounds and Study their Biological Activities

Year: 2024

Type: article

Abstract: Reaction 0f (thioacetamide/ acetemide) with chloroacetyl chloride to produced N-acetyl-2-chloro (thiocetamide/acetamide), then subsequent reaction with thiosemicarbazide to form N-acetyl-2-(2-carbamothioyl hydrazinyl)thioacetamide/acetamide. Ring closure or Cyclization of these compounds in the presence of sodium hydroxide yield N-(3-mercapto-1,4-dihydro-1,2,4 -triazin-5-yl)ethanethioamide/acetamide. The aim of this contribution is synthesis wide range of triazin derivatives by using different methodologies. These new triazine derivatives will be confirmed by FT- IR, 1HNMR, 13CNMR spectra. Since this triazine ring are very important core in chemical structure of some therapeutic compounds, will be evaluated for biological activities against two types of bacteria and fungi.

Source: International Journal of Innovative Science and Research Technology (IJISRT)

DOI: 10.38124/ijisrt/ijisrt24aug1311

Authors: Thamer Abd Rehan, Akram sadeq, Ahmad Rahman Salih

Institution: Ibn Sina University of Medical and Pharmaceutical Sciences

Language: English

Topic: Synthesis and Characterization of Heterocyclic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402496730