Year: 2024
Type: article
Abstract: Utilizing systematic plant chemistry separation techniques, two previously unreported phenolic acids (1-2) and eighteen (3-20) phenolic acids were isolated from 70 % ethanol extract of Meehania fargesii var. radicans (Vaniot) C.Y.Wu. The structures of the unreported compounds were determined using spectroscopic methods, including 1D and 2D NMR, ECD, and HR-ESI-MS. The activity of all isolated phenolic acids was evaluated for their ability to inhibit nitric oxide (NO) production in RAW264.7 cells activated by lipopolysaccharide (LPS). Among the isolated compounds, compounds 1 and 19 exhibited significant inhibitory activity against NO production in RAW264.7 cells, with higher concentrations being more active than the indomethacin, without displaying cytotoxicity. This study provides a basis for the application and development of M. fargesii and the discovery of natural anti-inflammatory drugs.
Source: Chemistry & Biodiversity
Authors: Xingpeng Liu, Jialiang Zhu, Jun Zeng, Mingming Qiao, Hanchuan Wang, Mingyi Shen, Dali Meng
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: bronze
Awards: G1183415604, G5229065197
OpenAlex ID: W4402499641