Work

Phages to the rescue: in situ editing of the gut microbiota

Year: 2024

Type: article

Abstract: The gut microbiome contains numerous bacteria tied to our health. However, genetically modifying this community remains a major challenge. Brödel et al. take a critical step by engineering bacteriophages to efficiently deliver gene editors without propagation of the genetic cargo, efficiently introducing edits to bacteria residing in the mouse gut.

Source: Trends in Microbiology

DOI: 10.1016/j.tim.2024.09.001

Authors: Charlotte Kamm, Chase L. Beisel

Institutions: Helmholtz Centre for Infection Research, Helmholtz Institute for RNA-based Infection Research, University of Würzburg

Language: English

Topic: Bacteriophages and microbial interactions

Subfield: Ecology

Field: Environmental Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $7,030

Funders: Deutsche Forschungsgemeinschaft, European Research Council, H2020 European Research Council