Work

The influence of the sizes of nanodiamond aggregates in their suspensions on the efficiency of sorption of 90Y and 177Lu isotopes for their subsequent use in nuclear medicine

Year: 2024

Type: article

Abstract: Nanodiamonds (NDs) are promising carriers of radionuclides in radiopharmaceuticals for use in nuclear medicine. In this work, we investigated the influence of the properties of ND suspensions, including the sizes of their aggregates, in aqueous solutions with different pH on their binding of medical isotopes 90Y and 177Lu and found the conditions for obtaining promising conjugates for further in vivo studies. It was shown that sorption is influenced by the composition of the solution, which determines the properties of the ND surface, while the forms of cations of the studied nuclides in the solution do not affect the degree of sorption.

Source: Radiokhimiya (U.S.S.R.) For English translation see Sov. Radiochem. (Engl. Transl.)

DOI: 10.31857/s0033831124020093

Authors: A. G. Kazakov, J. S. Babenya, T. Y. Ekatova, S. E. Vinokurov, E. Y. Khvorostinin, I. A. Ushakov, V. V. Zukau, E. S. Stasyuk, E. A. Nesterov, V. L. Sadkin, A. S. Rogov, B. F. Myasoedov

Institutions: Russian Academy of Sciences, V.I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Tomsk Polytechnic University

Language: English

Topic: Radiopharmaceutical Chemistry and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

Open Access status: bronze

OpenAlex ID: W4402504990

FWCI:

Cites: 16

Cited by:

Related to: 10