Work

The Vital Role of Immunohematology in Diagnosing Paroxysmal Cold Hemoglobinuria: A Clinical Case Report

Year: 2024

Type: article

Abstract: Paroxysmal cold hemoglobinuria (PCH) is a rare autoimmune hemolytic anemia caused by the binding of IgG immunoglobulins to red blood cells at cold temperatures, leading to hemolysis upon rewarming. The Donath-Landsteiner test can show biphasic hemolysis, leading to diagnosis. There is no consensus, but chemoimmunotherapy with or without plasma exchange is commonly employed. We present the case of a 42-year-old male who experienced symptoms of hemolysis after cold exposure in a semi-arid, warm-climate city.

Source: Cureus

DOI: 10.7759/cureus.69362

Authors: Willy Nava Gutiérrez, Paola Villa Cortés, Ricardo Ramírez Morales, Juan P Espinoza Garza, Jaime E Espinosa Mora

Institutions: University of Monterrey, Institute for Social Security and Services for State Workers

Language: English

Topic: Blood groups and transfusion

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402506852