Hereditary and Familial Traits in Urological Cancers and Their Underlying Genes
Year: 2024
Type: article
Abstract: Early recognition of hereditary urological cancers may influence diagnostic and therapeutic decision-making, and potentially alter the fate of patients and family members. Here, we introduce readers to the current knowledge on germline genetic testing and clinical practice in prostate, bladder, renal, and testicular carcinoma. Considering all urological cancer patients, routine inquiries about familial cancer history should become a standard practice in clinical settings. If suspicion arises, patients can opt for two avenues: referral to genetic counseling or undergoing genetic tests after consultation with the treating urologist. Patient summary: Tumors of the urogenital tract (prostate, kidney, bladder, and testes) can sometimes be related to genetic mutations that are present in all the cells of the body. Such mutations can be inherited and run in families. Therefore, it is relevant to obtain information on the incidence of all cancers in the family history. The information obtained may initiate genetic testing, leading to the identification of mutations that are related to cancer in the current or next generation. In addition, these mutations may offer alternative treatment options for patients.
Source: European Urology Open Science
Institutions: German Cancer Research Center, Charles University, Radboud University Medical Center, Harvard University, Dana-Farber Cancer Institute, Dana-Farber/Harvard Cancer Center, University of Helsinki, Helsinki University Hospital, Innsbruck Medical University, Universität Innsbruck, Erasmus MC, Erasmus MC Cancer Institute
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $1,800
Funder: Horizon 2020 Framework Programme
Award: G2080805274
OpenAlex ID: W4402507760