CNS Embryonal Tumor with PLAGL Amplification, a New Tumor in Children and Adolescents: Insights from a Comprehensive MRI Analysis
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND AND PURPOSE: amplification (ET, PLAGL) is a newly identified, highly malignant pediatric tumor. Systematic MRI descriptions of ET, PLAGL are currently lacking. MATERIALS AND METHODS: MRI data from 19 treatment-naïve patients with confirmed ET, PLAGL were analyzed. Evaluation focused on anatomic involvement, tumor localization, MRI signal characteristics, DWI behavior, and the presence of necrosis and hemorrhage. Descriptive statistics (median, interquartile range, percentage) were assessed. RESULTS: amplified tumors or compared with other embryonal CNS tumors. CONCLUSIONS: The study contributes to understanding the imaging characteristics of ET, PLAGL. It underscores the need for collaboration in studying rare pediatric tumors and advocates the use of harmonized imaging protocols for better characterization.
DOI: 10.3174/ajnr.a8496
Authors: A. Tietze, B. Bison, J. Engelhardt, T. Fenouil, D. Figarella-Branger, E. Goebell, J. Hakumäki, E. Koscielniak, L.E. Ludlow, D. Meyronet, P. Nyman, I. Øra, J. Pesola, T. Rauramaa, R.E. Reddingius, D. Samuel, A. Sexton-Oates, A. Vasiljevic, A.K. Wefers, J. Zamecnik, D.T.W. Jones, M.K. Keck, K. von Hoff, European Society for Paediatric Oncology (SIOPE)-Brain Tumour Group
Institutions: Humboldt-Universität zu Berlin, Charité - Universitätsmedizin Berlin, University of Augsburg, University Hospital Augsburg, Centre National de la Recherche Scientifique, Centre Hospitalier Universitaire de Bordeaux, Institut Polytechnique de Bordeaux, Institut de Mathématiques de Bordeaux, Hospices Civils de Lyon, Aix-Marseille Université, Institut de Neurophysiopathologie, Hôpital de la Timone, University Medical Center Hamburg-Eppendorf, University of Eastern Finland, Kuopio University Hospital, Olgahospital, Klinikum Stuttgart, Royal Children's Hospital, The University of Melbourne, Murdoch Children's Research Institute, Linköping University, Lund University, Linköping University Hospital, Children's Hospital Central California, Centre international de recherche sur le cancer, University Cancer Center Hamburg, Charles University, University Hospital in Motol, German Cancer Research Center, Heidelberg University, University Hospital Heidelberg, National Center for Tumor Diseases, Hopp Children's Cancer Center Heidelberg, Aarhus University Hospital, Freie Universität Berlin
Language: English
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4402508583