Work

pH-sensing GPR68 inhibits vascular smooth muscle cell proliferation through Rap1A

Year: 2024

Type: article

Abstract: Extracellular acidosis remains an understudied feature of many pathologies. We examined a potential regulatory role for pH-sensing GPR68 in vascular smooth muscle (VSM) growth in the context of CVD. With in vivo and in vitro growth models with GPR68-deficient mice and GPR68 induction strategies, novel findings revealed capacity of GPR68 to attenuate growth through the small GTPase Rap1A. These observations highlight GPR68 and its effector Rap1A as possible therapeutic targets to combat pathological VSM growth.

Source: American Journal of Physiology-Heart and Circulatory Physiology

DOI: 10.1152/ajpheart.00413.2024

Authors: Madison D. Williams, Joshua S. Morgan, Michael T. Bullock, Cere E. Poovey, Michael E. Wisniewski, Jake T. Francisco, Jerry A. Barajas-Nunez, Amira M. Hijazi, Drew Theobald, Srinivas Sriramula, Kyle D. Mansfield, Nathan A. Holland, David A. Tulis

Institutions: East Carolina University, Texas Tech University Health Sciences Center

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: American Cancer Society, National Institutes of Health, National Heart, Lung, and Blood Institute

Awards: Role of N6-Methyladenosine mRNA Modification in Breast Cancer Progression, Neuroimmune Mechanisms of Kinin B1 Receptor in Hypertension, Acid-sensing GPCRs in vascular inflammation and growth, G189082723, G2168727337, G393577494, G5452157991, G7068642749

OpenAlex ID: W4402515515

FWCI: 0.115

Cites: 68

Cited by: 1

Related to: 10