The relationship between obesity and the pathophysiology of gastrointestinal cancer, nutrition and the intestinal microbiota
Year: 2024
Type: article
Study design: Systematic Review
Abstract: Introduction: Obesity is linked to some types of cancer, such as those of the gastrointestinal tract (esophageal, liver, gallbladder, stomach, pancreas and colorectal cancer), ovary and thyroid. Objective: to describe the association of the main factors related to the relationship between obesity and the pathophysiology of gastrointestinal cancer, nutrition and the intestinal microbiota. Material and Methods: This article is a systematic review, based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology. Results and Discussion: Obesity increases the concentrations of insulin, IGF1 and IGF2, which in turn reduce apoptosis and stimulate cell growth. With increased adiposity, there is also an increased production of pro-inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-8 (IL-8), tumor necrosis factor (TNF) and C-reactive protein. Conclusion: Given the evidence presented in this study, it is observed that expanding adipose tissue may have a clinically relevant contribution to the development of gastric cancer. A greater understanding of the mechanisms of obesity-induced carcinogenesis is needed to develop methods to prevent or treat gastric cancer. A greater understanding of the molecular mechanisms present in obesity may lead to the identification of new therapeutic targets.
Authors: Hamilton Roberto M. de Oliveira Carriço, Jaqueline de Carvalho Ferreira, Giovana Casarini Yamashiro, Breno Freitas M. Cristino, Diógenes T. da Silva Oliveira, Délio Tiago M. Malaquias, Thales Corrêa De Oliveira, Gabriel Queiroz Sabbag, Laura Pontieri Biasotti, Alysson Corrêa A. Oliveira, Priscilla dos Santos D. Montalvão, Pâmela Christinny F.Viêra, Rubens Rodrigues Tudela, Aline Cristina C. da Silva, Gianluca França C. Sganzella, Rogério Leite Dos Santos, Jenyffer Victoria C. Villca, Hannah Kamarowski Fontana, Lucas Fernandes T. de Syllos, Ana Laura Nogueira Ervilha, Daniella Campos Furtado, Giovana Rocha Victorello, Ana Clara Pavaneli R. De Souza, Luana Mara De Lima, Rafaela Del Grosso Reis, Erica Miriam Fernandes M. Vão, Sadrak Horácio Cassoma, Elisitt Escarlet V. Cabrera, Luiza Goulart B. Bustamante, Viviane Ferrari Gomes, Thales Corrêa De Oliveira, Lucimara Pigaiani, José Vinícius Bicho Dos Reis, Charles do Nascimento M. Júnior, Pedro Dias Bezerra Neto, Juliana Fontes B. Paschoal, Thiago Augusto R. Bezerra
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4402516155