The association between toxicity and efficacy of immune checkpoint inhibitors in older adults with NSCLC
Year: 2024
Type: article
Study design: Observational Study
Abstract: Aim: This cohort study evaluated the association between immune checkpoint inhibitors (ICIs)-induced immune-related adverse events (irAEs) and mortality as well as ICI discontinuation among older adults with NSCLC.Methods: 2007–2019 Surveillance, Epidemiology and End Results-Medicare linked database was used and survival analysis with time-varying exposure of irAEs was applied to estimate the associations.Results & conclusion: A total of 8,175 individuals were included, with 46.8% of whom developed an irAE. Cox regression models showed the occurrence of any irAEs was associated with increased risk of mortality (HR: 1.73, 95% CI: 1.63–1.82) and treatment discontinuation (HR: 1.87, 95% CI: 1.78–1.97). Some variability was observed in the effect on the two outcomes depending on the type of irAE.
Source: Immunotherapy
Institution: University of Mississippi
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4402518950