Work

Novel PROTAC probes targeting KDM3 degradation to eliminate colorectal cancer stem cells through inhibition of Wnt/β-catenin signaling

Year: 2024

Type: article

Abstract: We designed and synthesized novel IOX1-based PROTACs, which can selectively degrade KDM3A and KDM3B to eliminate colorectal cancer stem cells through inhibition of Wnt signaling.

Source: RSC Medicinal Chemistry

DOI: 10.1039/d4md00122b

Authors: Shadid U. Zaman, Piyusha P. Pagare, Hongguang Ma, Rosalie G. Hoyle, Yan Zhang, Jiong Li

Institutions: Virginia Commonwealth University, VCU Massey Comprehensive Cancer Center

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Virginia Commonwealth University, Georgia Clinical and Translational Science Alliance, National Institutes of Health, National Institute of Dental and Craniofacial Research, National Center for Advancing Translational Sciences, Common Fund

Awards: G1124815663, G1574768020, G1850568578, G2024638873, G2842085025, G288283074, G3393630377, G4131135209, G5812495832, G6855548624, G9000087147, G9000267647

OpenAlex ID: W4402523748

FWCI: 1.505

Cites: 49

Cited by: 13

Related to: 10