Platelet factors ameliorate thoracic aortic aneurysm and dissection by inhibiting the FGF-FGFR cascade activation in aortic-endothelial cell
Year: 2024
Type: article
Abstract: , PF4 improved endothelial cell function under pathological conditions by inhibiting migratory and angiogenic abilities of human aortic endothelial cells (HAECs). Mechanically, PF4 inhibited the development of TAAD and improved HAECs function by combining with heparin sulfate and blocking fibroblast growth factor-fibroblast growth factor receptor (FGF-FGFR) signaling. Taken together, we developed a nano-drug (Lipo-PF4) that effectively ameliorates the progression of TAAD by improving endothelial function. Lipo-PF4 is expected to be a therapeutic option for TAAD in the future.
Source: iScience
Authors: Jizhong Wang, Caiyun He, Yuanwei Chen, Xiaolu Hu, Heng Xu, Jie Liu, Yi Yang, Lang Chen, Ting Li, Lixin Fang, Fan Yang, Jie Li, Jianfang Luo
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,150
Awards: G1476576080, G2314858409, G7529628343
OpenAlex ID: W4402526038