2-Arylbenzofurans from the stems and leaves of Artocarpus tonkinensis and their potential antiproliferative activities
Year: 2024
Type: article
Abstract: Phytochemical study on the stems and leaves of Artocarpus tonkinensis led to the isolation of a new 2-arylbenzofuran, artocartone (1), as well as seven known 2-arylbenzofurans (2–8). The chemical structure of 1 was established by means of comprehensive spectroscopic analyses and the known compounds were determined by comparing their MS and NMR data with those reported data in literature. The antiproliferative activities of all isolates 1–8 against five human cancer cell lines: HL-60, SMMC-7721, A-375, MCF-7 and SW480 in vitro were evaluated. As a result, compounds 1– 8 displayed notable antiproliferative activities against various human cancer cell lines with IC50 values in the range of 0.28 ± 0.05–26.89 ± 0.18 μM.
Source: Natural Product Research
Authors: Jia-Ming Guo, Lin-Xuan Li, Xin-Yi Li, Tian-Yu Wang, En-Ning Zhu, An-Jiao Wu, Shu-Ri Li, Hui- Yang, Yan-Ping Liu, Yan-Hui Fu
Institution: Hainan Normal University
Language: English
Topic: Bioactive natural compounds
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W4402528485