Work

Discordant myocardial perfusion defects and coronary artery disease – a multimodality imaging journey in the natural history of cardiac sarcoidosis

Year: 2024

Type: article

Abstract: Cardiac sarcoidosis is a rare form of systemic sarcoidosis characterized by formation of non-caseating granulomas in the myocardium, leading to heterogeneous manifestations, including conduction disturbances, arrhythmias, and heart failure. Besides myocardial fibrosis and structural myocardial alterations, cardiac sarcoidosis can impact the epicardial and microvascular circulation, causing ischemia and regional microvascular dysfunction. We present a case of cardiac sarcoidosis with atypical initial presentation but with evidence of disease in myocardial perfusion imaging, which was overlooked since it did not correspond to bystander coronary artery disease. Multimodality imaging facilitated diagnosis and offered insights into the regional microcirculation impairment caused by sarcoidosis-induced inflammation.

Source: The International Journal of Cardiovascular Imaging

DOI: 10.1007/s10554-024-03232-6

Authors: Andrei Galafton, Ronny R. Buechel, Fran Mikulicic, Philipp A. Kaufmann, Andreas A. Giannopoulos

Institutions: University of Zurich, University Hospital Zurich

Language: English

Topic: Sarcoidosis and Beryllium Toxicity Research

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,390