Association between body weight and tocilizumab effectiveness in rheumatoid arthritis: results from the BSRBR-RA
Year: 2024
Type: article
Abstract: OBJECTIVES: Tocilizumab is an IL-6 receptor humanized monoclonal antibody for the treatment of rheumatoid arthritis (RA) with intravenous (IV) and subcutaneous (SC) preparations available. Only IV tocilizumab is dosed adjusting for weight. Therefore, we aimed to study the association between body weight and the effectiveness of tocilizumab by the route of administration. METHODS: Patients with RA-administered tocilizumab in the BSRBR-RA were included in the analysis and stratified by route of administration. Outcomes included the 6-month change in DAS28, the proportion of patients achieving DAS28 remission, 6-month EULAR response and persistence of the first route of tocilizumab administration. The exposure was every increase in 10 kg of body weight. Adjusted regression models appropriate to outcome were used to study the associations between body weight and outcomes. Multiple imputations accounted for missing data. RESULTS: A total of 2612 patients were included. Body weight was associated with reduced response to SC tocilizumab measured by change in DAS28: adjusted regression coefficient (95% CI) all patients 0.01 (-0.04, 0.07); IV: -0.03, (-0.1, 0.5); SC: 0.1 (0.02, 0.2) but not odds in achieving DAS28 remission or EULAR response. There was no significant association between body weight and the persistence of IV or SC tocilizumab. CONCLUSION: Body weight was associated with the initial response to SC tocilizumab, although the difference in response was small, but not drug persistence. Physicians should monitor the body weight of patients and consider interventions to promote maintenance of a healthy weight.
Source: Lara D. Veeken
Authors: Man Fung Tsoi, Lianne Kearsley-Fleet, Narges Azadbakht, Kath Watson, Kimme L Hyrich, James Bluett, BSRBR-RA Contributors Group, Shabina Sultan, Chantel McParland, Lisa Armstrong, Emma Dooks, Anna Roynon Reed, Gemma Hodkinson, Maxine Nash, Meghan Brickley, Amanda Dell, Angela Hall, Clare Westacott, Jemma Tuffney, Roshen Sunil, Helen Hamilton, Rod Hughes, Maggie Walsh, Marie Buckley, Hisham Sharlala, Alice Nicholson, Anna Galvin, Sian Jones, Jamie Matthews, Scott Roantree, Hannah Brown, Joanne Howson, Kate Gamble, Lisa Reed, Susan Hope, Felice Rivellese, Frances Humby, Ayat Azhar, Emily Harvey, Mayisha Chowdhury, Fatima Bibi, Ishraat Miah, Muhammad Nisar, Philippa Bakker, Ruth Lovelock, Yasmeen Ahmad, Sion Lewis, Annette Bolger, Caroline Lees, Caroline Mulvaney Jones, Oluwatoyin Idowu, Victoria Garvey, Yasmeen Ahmad, Tahir Aziz, Sion Lewis, Caroline Mulvaney Jones, Yasmeen Ahmad, Emma McIvor, Caroline Mulvaney Jones, Claire Watkins, Mary Roberts, Victoria Whitehead, Melanie Caswell, Christopher Hale, Allison Clarke, Victoria Cunliffe, Omer Sharif, Kaitlin Boltwood, Molly Kelly, Andrew Haigh, Matthew Robinson, Kathryn Hanson, Lee-Ann Bayo, Miranda Usher, Sanya Anjam, Ashleigh Reeves, Lucia King, Andra Negoescu, Donna Abercrombie, Samantha Wright, Jane Rowlands, Ernest Choy, Kerry Nyland, Liz Harmer Griebel, Andrea Balan, Hoda Mirjafari-Temple, Theresa Barnes, Anna Hughes, Courtney Chard, Firdaus Shaikh, Lauren Slack, Lucy Slater, Phoebe Winstanley, Rebecca Noon, Keith Morris, Anna Williams, Charlotte Pickering, Helen Jeffrey, Jenny Grounds, Kathryn Cawley, Tazeen Ahmed, Gloria Nwajei-Agha, Bhathiya Wijeyekoon, Elizabeth Warner, Debbie Potter, Hannah Beadle, Susan Knight, Megan Young, Natalie Keenan, Maureen Holland, Kathryn Pointon, Syed Bari, Eva Beranova, Jhanielle Quindoyos, Natasha Schumacher, Reanne Solly, Sharon Turney, James Rand, Liam Austin, Louise Allen, Nikki Crisp, Olajumoke Owolabi, Tracy Hazelton, Gabriella Tutt, Heather Weston, Lee-Suan Teh, Annie Cheung, Sabeeh Shams, Shanoj Keezhoppattu Chathraikkal, Janice Hartley, Karen Davies, Hawa Desai, Rita Abdulkader, Deborah Beeby, Genessa Peters, Jenny Finch, Rebecca Francis, Ritu Malaiya, Kazi Fardeen, Rachel Hayre, Tina Raju, Ritu Malaiya, Jalpa Kotecha, Kazi Fardeen, Muhammed Russal Latheef, Rachel Hayre, Tina Raju, Alan Steuer, Amna Khawaja, Nicky Barnes, Fiona Wilson, Yasmina Ashour, Abid Yusuf, Laith Al Sweedan, Narender Singh, Danielle Suter, Jessica Gunn, David Boss, Sundip Gurung, Rebecca Walker, Nicola Westbrook, David Collins, Elizabeth Price, Alison Moon, Monica Schlup, Alina Gurung, Claire Potter, Helena Herbert, Lynne Kerton, Ruth Horton, Tracy Arnold, Bruce Kirkham, Katrina Frayna, Florence Enverga, Maria Opena, Nadia Ladha Hassan, Cristina Blanco-Gil, Lucy Brooks, Emma Williams, Emmanuel Defever, Emily Bevan, Jemima Parry, Christine Graver, Kerrie Taylor, Miyoba Lungu, Mike Green, Clare Stemp, Esther Gordon, Louise Brown, Nadira Singh
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $4,679
OpenAlex ID: W4402535133