Work

Nuciferine analogs block voltage-gated sodium, calcium and potassium channels to regulate the action potential and treat arrhythmia

Year: 2024

Type: article

Abstract: and normalize the HR, QRS, QT and QTc interval and the R wave amplitude. Moreover, 6a dose-dependently affected aconitine-induced arrhythmias and notably improved the cumulative dosage of aconitine required to evoke VP, VT, VF and CA in rats with aconitine-induced arrhythmia. In conclusion, nuciferine analogs could be promising ion channel blockers that could be further developed into antiarrhythmic agents.

Source: Biomedicine & Pharmacotherapy

DOI: 10.1016/j.biopha.2024.117422

Authors: Ying Xun Zhou, Wen Ping Wang, Jin Ke, Hui Ping Ou, Lin Yun Chen, An Guo Hou, Peng Li, Yun Shu Ma, Wen Bin Jin

Institutions: Yunnan University of Traditional Chinese Medicine, Hong Kong Polytechnic University, Shenzhen Polytechnic University

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,420

Funders: National Natural Science Foundation of China, Natural Science Foundation of Yunnan Province, Yunnan Provincial Department of Education, Science, Technology and Innovation Commission of Shenzhen Municipality, Basic and Applied Basic Research Foundation of Guangdong Province

Awards: G389941610, G5436178395, G7140105262, G8943247620

OpenAlex ID: W4402535779

FWCI: 1.603

Cites: 37

Cited by: 6

Related to: 10