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Three-dimensional gas-foamed scaffolds decorated with metal phenolic networks for cartilage regeneration

Year: 2024
Type: article
Abstract: Inflammation is a major impediment to the healing of cartilage injuries, yet bioactive scaffolds suitable for cartilage repair in inflammatory environments are extremely rare. Herein, we utilized electrospinning to fabricate a two-dimensional nanofiber scaffold (2DS), which was then subjected to gas foaming to obtain a three-dimensional scaffold (3DS). 3DS was modified with metal phenolic networks (MPNs) composed of epigallocatechin gallate (EGCG) and strontium ions (Sr 2+ ) to afford a MPNs-modified 3D scaffold (3DS-E). Gas-foamed scaffold exhibited multilayered structure conducive to cellular infiltration and proliferation. Compared to other groups, 3DS-E better preserved chondrocytes under interleukin (IL)-1β induced inflammatory environment, showing less apoptosis of chondrocytes and higher expression of cartilage matrix. Additionally, 3DS-E facilitated the regeneration of more mature cartilage in vivo , reduced cell apoptosis, and decreased the expression of pro-inflammatory cytokines. Taken together, 3DS-E may offer an ideal candidate for cartilage regeneration.
DOI: 10.1016/j.mtbio.2024.101249
Authors: Yujie Chen, Wei Xu, Zhen Pan, Bohui Li, Xiumei Mo, Yucai Li, Jielin Wang, Yuan Wang, Zhenyuan Wei, Yicheng Chen, Zhaopu Han, Chen Lin, Yu Liu, Xiaojian Ye, Jiangming Yu
Institutions: Shanghai Jiao Tong University, Tongren Hospital, Shandong University, Donghua University, State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Tongji University, Shanghai East Hospital
Language: English
Subfield: Biomaterials
Open Access status: gold
Estimated APC paid: $3,150
OpenAlex ID: W4402536206
FWCI: 1.252
Cites: 39
Cited by: 15
Related to: 10