Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study
Year: 2024
Type: article
Study design: Observational Study
Abstract: Resting-state functional connectivity (FC) MRI is sensitive to brain changes in Alzheimer's disease in preclinical stages, however studies in persons with subjective cognitive decline (SCD) have reported conflicting findings, and no study is available at 7T MRI. In this study, we investigated FC alterations in sixty-six participants recruited at the Geneva Memory Center (24 controls, 14 SCD, 28 cognitively impaired [CI]). Participants were classified as SCD if they reported cognitive complaints without objective cognitive deficits, and underwent 7T fMRI to assess FC in canonical brain networks and their association with cognitive/clinical features. SCD showed normal cognition, a trend for higher depressive symptoms, and normal AD biomarkers. Compared to the other two groups, SCD showed higher FC in frontal default mode network (DMN) and insular and superior temporal nodes of ventral attention network (VAN). Higher FC in the DMN and VAN was associated with worse cognition but not depression, suggesting that hyper-connectivity in these networks may be a signature of age-related cognitive decline in SCD at low risk of developing AD.
Source: Neurobiology of Aging
Institutions: Centro San Giovanni di Dio Fatebenefratelli, University of Geneva, University Hospital of Geneva, Centre d'Imagerie BioMedicale, École Polytechnique Fédérale de Lausanne, Swiss Center for Electronics and Microtechnology (Switzerland), University of Trento, Centre Hospitalier Universitaire Vaudois, University of Lausanne
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,330
Funders: National Science Foundation, European Commission, École Polytechnique Fédérale de Lausanne, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, Hôpitaux Universitaires de Genève, Université de Genève, Université de Lausanne, Centre d'Imagerie BioMédicale, Centre Hospitalier Universitaire Vaudois, Fondation Segré, Avid Radiopharmaceuticals
Awards: Individual cognitive risk profiling in aging according to Amyloid, Tau and Neurodegeneration imaging biomarkers, Bridging gaps in the neuroimaging puzzle: advanced techniques for comprehensive mapping of brain anatomy and multi-scale network activity, The Biological Basis of Cognitive Impairment due to Suspected Non-Alzheimer’s Pathology (SNAP) : Studying the interplay between amyloidosis and tau-related neurodegeneration, Brain connectivity and metacognition in persons with subjective cognitive decline (COSCODE): correlation with clinical features and in vivo neuropathology, Common mechanisms and pathways in Stroke and Alzheimer's disease.
OpenAlex ID: W4402538191