Homologous cell membrane-based hydrogel creates spatiotemporal niches to improve outcomes of dysregulated chronic wound healing
Year: 2024
Type: article
Abstract: The (M2M + TGF-β)@HAMA hydrogel dressing improves the outcomes of dysregulated chronic wound healing by protecting the open wound from repeated bacterial infections, reprogramming endogenous monocytes and M1 macrophages into an M2-phenotype, as well as enhancing fibroblastic proliferation and migration for matrix remodeling and granulation tissue formation. • Cell membrane-based hydrogel creates spatiotemporal niches for macrophage reprogramming. • M1-M2 transition in macrophage phenotype is induced in an epigenetic manner. • Interactions between macrophages and fibroblasts synergistically promote dysregulated chronic wound healing.
Source: Materials Today Bio
Authors: Yijuan Ding, Qi Jia, Ziwen Su, Heying Chen, Jialing Ye, Dafeng Xie, Yubo Wu, Haiyan He, Yanlin Peng, Yilu Ni
Institution: Chongqing Medical University
Language: English
Topic: Wound Healing and Treatments
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,150
OpenAlex ID: W4402540164