Novel Type of Non‐Toxic, Degradable, Luminescent Ratiometric Thermometers Based on Dyes Embedded in Disulfide‐Bridged Periodic Mesoporous Organosilica Particles
Year: 2024
Type: article
Abstract: Despite the excellent thermometric performance of many developed luminescent nanomaterials, their use has not gone beyond proof‐of‐concept in vivo experiments to date. An important issue that needs to be resolved before moving toward true biomedical applications of engineered nanothermometers is their potential toxicity and bioaccumulation in the human body considering the ultimate objective of clinical applications. Since most reported nanothermometers currently are not degradable materials and are mainly based on the incorporation of heavy metal ions, these aspects remain of genuine concern in the fields of nanomedicine, nanobiotechnology, nanotoxicology, and nanopharmacology. This work explores the possibility of designing visible, as well as near‐infrared, emitting luminescent ratiometric nanothermometers based on appropriate organic dye mixtures embedded in hollow disulfide‐bridged periodic mesoporous organosilica (PMO) particles. Such hybrid particles show excellent thermometric performance in the physiological temperature range (20–50 °C), favorable degradability in simulated physiological conditions, as well as no toxicity to healthy normal human dermal fibroblast (NHDF) cells in a wide concentration range. Considering the simplicity of the approach from the synthetic point of view, and the large available library of known fluorescent dyes emitting in various regions of the electromagnetic range, this motif renders a very promising approach to designing novel non‐toxic, decomposable, luminescent ratiometric thermometers.
Source: Advanced Optical Materials
Authors: Simona Premcheska, Mirijam Lederer, Sonali Mohanty, Ayse Alici, Andre G. Skirtach, Anna M. Kaczmarek
Institution: Ghent University
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
Awards: Magnetic resonance equipment for advanced material research: molecular characterisation of solid, soft, homogeneous and heterogeneous matter for the development of advanced functional materials and chemical catalysis, G1435255865, NanOthermomteRs for THeranostics, G2492948467, G3406071447, G434337789, G7939529489, G8383284812, G8441999294
OpenAlex ID: W4402540628