Year: 2024
Type: article
Abstract: The dorsolateral prefrontal cortex (dlPFC) is reliably engaged in working memory (WM) and comprises different cytoarchitectonic layers, yet their functional role in human WM is unclear. Here, participants completed a delayed-match-to-sample task while undergoing functional magnetic resonance imaging (fMRI) at ultra-high resolution. We examine layer-specific activity to manipulations in WM load and motor response. Superficial layers exhibit a preferential response to WM load during the delay and retrieval periods of a WM task, indicating a lamina-specific activation of the frontoparietal network. Multivariate patterns encoding WM load in the superficial layer dynamically change across the three periods of the task. Last, superficial and deep layers are non-differentially involved in the motor response, challenging earlier findings of a preferential deep layer activation. Taken together, our results provide new insights into the functional laminar circuitry of the dlPFC during WM and support a dynamic account of dlPFC coding.
Source: Communications Biology
Institutions: Humboldt-Universität zu Berlin, Max Planck Institute for Human Cognitive and Brain Sciences, Bernstein Center for Computational Neuroscience Berlin, Charité - Universitätsmedizin Berlin, MRC Cognition and Brain Sciences Unit, University of Cambridge, Technische Universität Berlin, Freie Universität Berlin, Technische Universität Dresden, Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, Leipzig University, Max Planck Institute for Biological Cybernetics
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,890
Awards: Cooperating brain systems in attention and control, IronSleep - Neurobildgebungs- und Schlafbiomarker für die Früherkennung und Verlaufskontrolle der Parkinson-Krankheit und Untersuchung der zugrundeliegenden Mechanismen, G339059223, G434337789, G5771730111, Fractionating the human frontoparietal cortex: combining meta-analytic and real-time optimization approaches, Ein umfassendes mikrostrukturelles Connectom des menschlichen Gehirns (COMIC): Von langen Nervenfasern zu kurzen Assoziationsfasern, G7464934001, Antibodies against Nogo-A to enhance plasticity, regeneration and functional recovery after acute spinal cord injury, a multicenter European clinical proof of concept trial
OpenAlex ID: W4402543772