Year: 2024
Type: review
Abstract: Cardiovascular diseases persist as a global health challenge that requires methodological innovation for effective drug development. Conventional pipelines relying on animal models suffer from high failure rates due to significant interspecies variation between humans and animal models. In response, the recently enacted Food and Drug Administration Modernization Act 2.0 encourages alternative approaches including induced pluripotent stem cells (iPSCs). Human iPSCs provide a patient-specific, precise, and screenable platform for drug testing, paving the way for cardiovascular precision medicine. This review discusses milestones in iPSC differentiation and their applications from disease modelling to drug discovery in cardiovascular medicine. It then explores challenges and emerging opportunities for the implementation of 'clinical trials in-a-dish'. Concluding, this review proposes a framework for future clinical trial design with strategic incorporations of iPSC technology, microphysiological systems, clinical pan-omics, and artificial intelligence to improve success rates and advance cardiovascular healthcare.
Source: European Heart Journal
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: G2128837412, Elucidating Cardiac Fibroblast Activation at Single-cell Resolution, G4999666563, G5171724592, G6955760727, Air Pollution-induced Epigenomic Changes in Human Cardiac Organoids, G870798204, Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology, Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy, Single-cell Multi-omic Profiling of Drug Responses Using Pooled iPSC-CM Differentiation, High Mechanical Shear Stress-Induced Neutrophil Dysfunction in Mechanically Assisted Circulation, Modeling Tyrosine Kinase Inhibitor-Induced Vascular Dysfunction Using Human iPSCs
OpenAlex ID: W4402544017