Work

Unlocking fresh perspectives: molecular breakthroughs in pediatric acute myeloid leukemia classification and prognosis

Year: 2024

Type: article

Abstract: clinical outcomes, molecular categories, pediatric acute myeloid leukemia, risk stratification Recently, a novel transcriptome and genome profiling study published in the Journal of Nature Genetics, expanded the prognosis-related molecular classification coverage of pediatric acute myeloid leukemia (pAML) from 68.5% (as defined by the WHO 5th edition) to 91.4%. 1 This framework was strongly associated with clinical outcomes, potentially shaping future classifications and treatment of pediatric AML.Differences in molecular profiles between pediatric and adult AML restrict the use of risk stratification tools designed for adults when applied to pediatric patients.For instance, while the TP53 mutation, present in about 8% of adult AML cases and linked to poor outcomes, is emphasized in the European LeukemiaNet (ELN) 2022 guidelines, 2 it is infrequently observed in pediatric AML.

Source: MedComm

DOI: 10.1002/mco2.750

Authors: Yu Tao, Li Wei, Hua You

Institutions: Children's Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing Population and Family Planning Science and Technology Research Institute

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,500