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Exogenous interactome analysis of bovine viral diarrhea virus-host using network based-approach and identification of hub genes and important pathways involved in virus pathogenesis

Year: 2024
Type: article
Abstract: Bovine viral diarrhea (BVD) is one of the most important diseases in livestock, caused by BVD virus (BVDV). During the pathogenesis of the virus, many interactions occur between host and viral proteins. Studying these interactions can help better understand the pathogenesis of the virus, identify putative functional proteins, and find new treatment and prevention strategies. To this aim, a BVDV-host protein-protein interaction (PPI) network map was constructed using Cytoscape and analyzed with cytoHubba, Kyoto Encyclopedia of Genes and Genomics (KEGG), Gene Ontology (GO), and Protein Analysis Through Evolutionary Relationships (PANTHER). N pro with 125 connections had the greatest number of interactions with host proteins. CD46 , EEF -2, and TXN genes were detected as hub genes using different ranking algorithms in cytoHubba. BVDV interactions with its host mainly focus on targeting translation, protein synthesis, and cellular metabolism pathways. Different classes of proteins including translational proteins, nucleic acid metabolism proteins, metabolite interconversion enzymes, and protein-modifying enzymes are affected by BVDV. These findings improve our understanding of the effects of the virus on the cell. Hub genes and key pathways identified in the present study can serve as targets for novel BVDV prevention or treatment strategies. • BVDV-host interactions are mainly focused on targeting the translation, protein synthesis, and cellular metabolism pathways. • N pro of BVDV has the greatest number of interactions with host proteins. • CD46 , EEF -2, and TXN genes are hob genes.
DOI: 10.1016/j.bbrep.2024.101825
Language: English
Open Access status: gold
Estimated APC paid: $2,540
OpenAlex ID: W4402554600
FWCI:
Cites: 65
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Related to: 10