Impact of Pre-Adolescent Substance Familiarity on Subsequent Use: Longitudinal Analysis of Risk by Latent Classes in the Adolescent Brain Cognitive Development Sample
Year: 2024
Type: article
Abstract: Background Predicting substance use in adolescence is a difficult yet important task in developing effective prevention. We aim to extend previous findings on the linear associations between familiarity with (knowledge of) substances in childhood and subsequent substance use in adolescence through a latent class analysis (LCA) to create risk profiles based on substance familiarity.Method Using the ABCD Study® sample, we conducted an LCA using 18 binary substance familiarity variables (n = 11,694 substance-naïve youth). Complementary analyses investigated the relationship between LCA groups and (1) longitudinal use, (2) use initiation, and (3) early use.Results The optimal LCA resulted in a four-class solution: Naïve, Common, Uncommon, and Rare, with each group increasing in both the number and rarity of known substances. Analysis 1 revealed an increased risk in use over time among both the Uncommon and Rare groups (ORs = 2.08 and 5.55, respectively, p’s < 0.001) compared to the Common group. Analysis 2 observed a decreased risk for initiation between the Naïve and Common groups (OR = 0.61, p = 0.009); however, the Uncommon and Rare groups were at an increased risk compared to the Common group (ORs = 2.08 and 3.42, respectively, p’s < 0.001). Analysis 3 found an increased risk of early use between the Common and Uncommon groups (OR = 1.92, p < 0.001) with a similar trend between the Common and Rare groups (OR = 1.90, p = 0.06).Conclusion These results highlight distinct risk profiles for adolescent substance use based on substance familiarity in middle childhood. Current work could be applied as an early screening tool for clinicians to identify those at risk for adolescent substance use.
Source: Substance Use & Misuse
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1020259976, G1058358382, G1436251778, G1510635755, G1555162842, G1569016918, G1586463187, G1742849658, G201257335, G2715786902, G2735337927, G2998093352, G3305455594, Identification of Prospective Predictors of Alcohol Initiation During Early Adolescence, G343603955, G3438786812, G3563224455, G3738900353, G3755973507, G4066048162, G4180929035, G4241744443, G469525291, G4962671277, G5002640097, G5081895789, G5139799579, G515074673, G5976565686, G687916792, G6887863799, G6922259526, G6983123888, G7271102572, G7652160222, G771167098, G815084465, G8281824583, Enhancing Recovery Outcomes in Alcohol Use Disorder: Cognitive Training as an Adjunct to Treatment, G8679417706, G8762821959, G8865478933, G9000006386, G9000008241, G9000025347, G9000034221, G9000042425, G9000046731, G9000047156, G9000061868, G9000108491, G9000112882, G9000113866, G9000163168, G9000202101, G9000205938, G9000241459, G9000286149, 9/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT U MICHIGAN, 17/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UCLA, 8/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT CHLA, 6/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT OHSU, 21/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT WUSTL, 2/21 ABCD-USA CONSORTIUM: RESEARCH PROJECT SITE AT UMB, G923039674
OpenAlex ID: W4402555102