The Environmental Enteric Dysfunction Biopsy Initiative (EEDBI) Consortium: mucosal investigations of environmental enteric dysfunction
Year: 2024
Type: article
Abstract: Environmental enteric dysfunction (EED) is an asymptomatic acquired disorder characterized by upper small bowel inflammation, villus blunting, and gut permeability. It is a major contributor to poor growth in childhood as well as other highly consequential outcomes such as delayed neuorcognitive development. After decades of intermittent interest in this entity, we are now seeing a resurgence in the field of EED. However, recent studies have been hampered by a lack of investigation of the target tissue-the upper small bowel. In 2016, the EEDBI (Environmental Enteric Dysfunction Biopsy Initiative) Consortium was established as a common scientific platform across 3 independent EED biopsy cohort studies in Bangladesh, Pakistan, and Zambia. Two centers in the United States recruited comparison groups of children undergoing endoscopy for clinical indications. The EEDBI Consortium goal was to augment the contributions of the individual centers and answer high-level questions amenable to analysis and interpretation across the studies. Here, we describe the Consortium and its cohorts and recruitment procedures across studies. We also offer details applicable to all papers in this supplement, which describe EED mucosal histology, morphometry, immunohistochemistry, and transcriptomics as well as histology relationship to pathogens and biomarkers.
Authors: Donna M Denno, Sheraz Ahmed, Tahmeed Ahmed, S Asad Ali, Beatrice Amadi, Paul Kelly, Sarah Lawrence, Mustafa Mahfuz, Chelsea Marie, Sean R Moore, James P Nataro, William A Petri, Peter B Sullivan, Phillip I Tarr, Kumail Ahmed, Md Ashraful Alam, Barrett H Barnes, SM Khodeza Nahar Begum, Stephen M Borowitz, Kanta Chandwe, Miyoba Chipunza, Subhasish Das, Lee A Denson, Jeffrey R Donowitz, Shah Mohammad Fahim, Md Amran Gazi, Carol A Gilchrist, Rashidul Haque, Md Mehedi Hasan, Md Shabab Hossain, Aneeta Hotwani, Junaid Iqbal, Najeeha Talat Iqbal, Sadaf Jakhro, Furqan Kabir, Barbara J Mann, Ramendra Nath Mazumder, Waheeda Memon, Jeremy P Middleton, Uma Nayak, Sandra Oliphant, Abdul Khalique Qureshi, Masudur Rahman, Najeeb Rahman, Girija Ramakrishnan, Kamran Sadiq, Shafiqul Alam Sarker, Fayaz Umrani
Institutions: University of Washington, Aga Khan University, International Centre for Diarrhoeal Disease Research, University of Zambia, Tropical Gastroenterology & Nutrition group, Queen Mary University of London, Blizard Institute, University of Virginia, University of Oxford, Washington University in St. Louis, University of Virginia Children's Hospital
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $5,100
Awards: G1586666568, G3027883970, Queen Mary & Westfield College - to work with colleagues to identify and evaluate candidate biomarkers of environmental enteropathy, which causes growth failure in children in the ..., G444632500, G6244314524, G6873629213, G8548573927, G8569205002, Host-environment interactions in the pathophysiology of digestive disease
OpenAlex ID: W4402563475