Differing Pattern of Mismatch Negativity Responses in Clinical and Nonclinical Voice Hearers Challenge Predictive Coding Accounts of Psychosis
Year: 2024
Type: article
Study design: Observational Study
Abstract: Among people with schizophrenia (PSZ), reduced mismatch negativity (MMN) is conceptualized as evidence of disrupted prediction error signaling that underlies positive symptoms. However, this conceptualization has been challenged by observations that MMN and positive symptoms are often uncorrelated. In the current study, we tested the hypothesis that reduced MMN is associated with the presence of hallucinations and delusions specifically rather than the presence of a psychiatric illness. A second aim was to determine whether the strength of the association with positive symptoms increases for indices that reflect predictions at higher levels of abstraction. Fifty-six PSZ, 34 nonclinical voice hearers, and 48 healthy comparison subjects (HCs) completed 2 MMN paradigms: one with a simple duration deviant type, and one with a higher-level, pattern-violation deviant type. We also measured the repetition positivity, which reflects the formation of auditory memory traces. We observed that although PSZ exhibited the expected pattern of significantly reduced duration MMN and reduced pattern-violation MMN at the trend level compared with HCs, nonclinical voice hearers exhibited a pattern of duration MMN and pattern-violation MMN amplitude that was statistically similar to that of HCs ( p s > .64). Similarly, PSZ exhibited a significantly reduced repetition positivity slope compared with HCs in the duration condition and a trend-level reduction compared with HCs in the pattern-violation condition. Nonclinical voice hearers did not differ from either group in repetition positivity slope in either condition. These results indicate that the MMN as a prediction error signal does not reflect processes relevant for the manifestation of hallucinations and delusions. To test the hypothesis that prediction errors as measured by the mismatch negativity (MMN) are uniquely associated with positive symptoms of schizophrenia (i.e., hallucinations and delusions) as opposed to other aspects of the illness (i.e., functional impairment), we measured MMN and the related repetition positivity in people with schizophrenia, nonclinical voice hearers (NCVHs), and healthy comparison subjects (HCs). We found that MMN among NCVHs was similar to that among HCs, indicating that MMN abnormalities may be more strongly associated with the diagnosis of schizophrenia and/or the risk factors associated with it than with positive symptoms per se.
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,500
OpenAlex ID: W4402563821