Work

Multifunctional Bi2S3-Au nanoclusters for fluorescence/infrared thermal imaging guided photothermal therapy

Year: 2024

Type: article

Abstract: Nanotechnology has attracted extensive attention in the diagnosis and treatment of cancer. Therefore, the research aimed at developing new nanomaterials and exploring their applications in biomedicine has attracted more attention. In this study, Bi 2 S 3 -Au nanoclusters (Bi 2 S 3 -AuNCs) as fluorescence/infrared thermal imaging-guided photothermal therapy (PTT) was prepared for the first time. It was achieved in a facile and mild way by optimizing the amount of Bi 3+ and Au 3+ using bovine serum albumin (BSA) as reducer and stabilizer. The as-prepared Bi 2 S 3 -AuNCs with special morphology showed high stability, excellent biocompatibility and good photostability. Apart from these, it also can accumulate at tumor sites and exhibit considerable fluorescence/infrared thermal imaging-guided PTT. Bi 2 S 3 -AuNCs nanoparticles integrate imaging and therapeutic functions into an advanced application platform, which provides the possibility to build a novel nano-cancer diagnosis and treatment platform.

Source: International Journal of Pharmaceutics X

DOI: 10.1016/j.ijpx.2024.100286

Authors: Hongmei Sun, Yuyu Cao, Beibei Zhai, Xiaoshuang Zhao, Xuejun Zhang, Jiangtao Su

Institutions: Hubei University of Technology, Hubei Bio Pharmaceutical Industry Technology Institute (China), Humanwell Healthcare Group (China)

Language: English

Topic: Nanoplatforms for cancer theranostics

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,700