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Pure Red Cell Aplasia in a Patient with Thymic Hyperplasia, Hypogammaglobulinemia and Adult T-cell Leukemia/Lymphoma

Year: 2024

Type: article

Abstract: Acquired pure red cell aplasia (PRCA), caused by thymic hyperplasia, is extremely rare. We herein report a previously healthy 41-year-old man who presented with severe anemia, lymphadenopathy, an upper mediastinal mass, and hypogammaglobulinemia. The patient was eventually diagnosed with PRCA and adult T-cell leukemia/lymphoma (ATLL). The mediastinal mass was pathologically diagnosed as thymic hyperplasia without clear ATLL invasion. Although his anemia improved rapidly after thymectomy, PRCA recurred approximately 500 days later and was accompanied by ATLL exacerbation. The findings in this patient suggest that the Good's syndrome-like symptoms (thymic hyperplasia and hypogammaglobulinemia) in this patient and PRCA may have been paraneoplastic syndromes caused by ATLL.

Source: Internal Medicine

DOI: 10.2169/internalmedicine.4443-24

Authors: Yasushi Kubota, Haruhiko Sano, Yuji Takeda, Kyosuke Yamaguchi, Hideaki Nakamura, Keita Kai, Keisuke Kidoguchi, Kana Kusaba, Masako Yokoo, Toshihiko Ando, Eisaburo Sueoka, Shinya Kimura

Institutions: Saga University, Saga-Ken Medical Centre Koseikan

Language: English

Topic: T-cell and Retrovirus Studies

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4402564146

FWCI:

Cites: 22

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Related to: 10