Work

Hovenia dulcis Thunb. monofloral honey attenuates LPS-induced inflammation and endotoxemia through the activation of the Nrf2/HO-1 axis

Year: 2024

Type: article

Abstract: , as well as cytokines, including tumor necrosis factor-α and interleukin-12 in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, by inhibiting NF-κB activation. Additionally, HMH prevented mortality and abnormalities in LPS-microinjected zebrafish larvae along with the inhibition of proinflammatory genes. In addition, HMH was found to reduce mitochondrial membrane potential depolarization and mitochondrial reactive oxygen species production in both LPS-stimulated RAW 264.7 macrophages and zebrafish larvae. Furthermore, HMH induced the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) and promotes the nuclear translocation of Nrf2. The anti-inflammatory effects of HMH are mediated via the Nrf2-HO-1 axis, and an HO-1 inhibitor reverses HMH-induced responses. This study is the first to demonstrate the anti-inflammatory and anti-endotoxemic effects of HMH, highlighting its potential as a therapeutic.

Source: Journal of Traditional and Complementary Medicine

DOI: 10.1016/j.jtcme.2024.09.003

Authors: Wisurumuni Arachchilage Hasitha Maduranga Karunarathne, Sungjoon Na, Mi-Hwa Lee, Chang-Hee Kang, Yung Hyun Choi, Gi-Young Kim

Institutions: University of Ruhuna, Jeju National University, Nakdonggang National Institute of Biological Resources, Dong-Eui University

Language: English

Topic: Genomics, phytochemicals, and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Ministry of Environment, U.S. Forest Service, Korea Environmental Industry and Technology Institute, Korea Forest Service