Work

Visible‐Light‐Mediated Copper(I)‐Catalyzed Regiospecific Amino‐Hydroxylation and Amino‐Alkoxylation of Vinyl Arenes

Year: 2024

Type: article

Abstract: Aminohydroxylation of alkene is an important method for synthesizing 1,2‐amino alcohols, which are found in natural products, pharmaceutically active compounds, and several marketed drugs. Herein, we report the development of visible‐light mediated copper‐catalyzed aminohydroxylation and aminoalkoxylation of alkenes. In contrast to expensive iridium, ruthenium, or organic‐dyes‐based photocatalysts, this protocol takes advantage of economical copper phenanthroline complex as a photocatalyst for the generation of N‐centred radical from N‐amino pyridinium salt. Furthermore, this protocol features mild reaction conditions, a broad substrate scope, and regiospecific.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202400996

Authors: Baldau Singh, Tiwari Neeraj Brijbhushan, Krishn Kumar, Piyush Pandey, Dhandapani Ganapathy

Institution: Indian Institute of Technology Bhilai

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Indian Institute of Technology Bhilai, Science and Engineering Research Board

Awards: G2675367590, G7477203976