Work

Modular Access to Aryl Quinolinyl Ketones via Visible‐Light‐Induced Palladium‐Catalyzed Aldehyde C−H Bond Arylation of Quinoline‐8‐Carbaldehydes with Arylboronic Acid

Year: 2024

Type: article

Abstract: This article describes the development of a room‐temperature visible‐light‐induced palladium‐catalyzed directed aldehyde C−H bond arylation to access aryl quinolinyl ketones. In this pathway, the Pd catalyst plays a dual role by harvesting light as a photocatalyst and catalyzing the chemical transformation via C−H bond activation. This process is general to synthesize a range of aryl quinolinyl ketones and tolerates many common functional groups. Our methodology was successfully applied to synthesize highly potent tubulin polymerization inhibitors.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.202400549