Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVE: To examine whether changes in survival without moderate or severe neurodevelopmental impairment (NDI) at 18-26 months' corrected age from 1999 to 2018 differed between male and female infants. DESIGN: This retrospective cohort study used data from the NICHD Neonatal Research Network hospitals. Robust Poisson regression models were used to estimate adjusted relative risks (aRRs) and 95% CIs for survival without moderate or severe NDI between males and females. Interactions between sex and time were assessed to evaluate temporal differences in the outcome by sex. Variables adjusted for included centre, maternal age, ethnicity/race, gestational age and small for gestational age. PATIENTS: Inborn infants with gestational age of 22-26 weeks at NICHD Neonatal Research Network hospitals from 1999 to 2018. MAIN OUTCOME MEASURE: Change over time in survival without moderate or severe NDI at 18-26 months' corrected age between male and female infants. RESULTS: Of 26 307 infants, 13 045 (49.6%) were male. Survival without moderate or severe NDI declined for both sexes over time, from 32.9% to 30.6% for males and from 47.4% to 40.0% for females, between 1999-2003 and 2014-2018. Males were less likely than females to survive without moderate or severe NDI (aRR=0.80; 95% CI 0.78 to 0.83). Changes in survival without moderate or severe NDI did not differ between males and females. CONCLUSION: There were no differential changes in survival without moderate or severe NDI between male and female infants.
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, University of Cincinnati, RTI International, National Institutes of Health, Pritzker School of Medicine, National Institute of Child Health and Human Development, National Center for Research Resources, National Center for Advancing Translational Sciences, National Institute on Minority Health and Health Disparities, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1112584313, General Clinical Research Center, GENERAL CLINICAL RESEARCH CENTER, G1655184841, G1979271746, G198169237, G210410618, NICHD Neonatal Research Network (NRN), G3558224168, G3681958810, G3703661376, G4042439704, G4137622978, G4178252161, G4219375103, G4572800114, Cooperative Multicenter Network of Neonatal Intensive Care Units, NICHD Cooperative Multicenter Neonatal Research Network, G4871569943, G4923448371, G5163102165, G5332205520, G618781263, G620193075, G6279089317, G6558373809, General Clinical Research Center, G7485331704, Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network, Development and evaluation of a risk-based approach to target vitamin A therapy to prevent bronchopulmonary dysplasia among very low birth weight infants, G8429050513, MULTICENTER NETWORK OF NEONATAL INTENSIVE CARE UNITS, NICHD Neonatal Research Network Clinical Center UAB, NICHD Cooperative Multicenter Neonatal Research Network - Utah Center, NICHD Neonatal Research Network - Stanford University, NICHD Neonatal Research Network Clinical Center - Case Western Reserve University, NICHD Neonatal Research Network
OpenAlex ID: W4402574490