Is speech function lateralised in the basal ganglia? Evidence from de novo Parkinson’s disease
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Research on the possible influence of lateralised basal ganglia dysfunction on speech in Parkinson's disease is scarce. This study aimed to compare speech in de-novo, drug-naive patients with Parkinson's disease (PD) with asymmetric nigral dopaminergic dysfunction, predominantly in either the right or left hemisphere. METHODS: Acoustic analyses of reading passages were performed. Asymmetry of nigral dysfunction was defined using dopamine transporter-single-photon emission CT (DAT-SPECT). RESULTS: From a total of 135 de novo patients with PD assessed, 47 patients had a lower right and 36 lower left DAT availability in putamen based on DAT-SPECT. Patients with PD with lower left DAT availability had higher dysarthria severity via composite dysarthria index compared with patients with lower right DAT availability (p=0.01). CONCLUSION: Our data support the crucial role of DAT availability in the left putamen in speech. This finding might provide important clues for managing speech following deep brain stimulation.
Authors: Jan Rusz, Petr Dusek, Tereza Tykalova, Michal Novotny, Vojtech Illner, Michal Simek, Tomas Kouba, Petr Kryze, David Zogala, Evzen Ruzicka, Mário Sousa, Adriana Jorge, Tobias Nef, Paul Krack
Language: English
Topic: Voice and Speech Disorders
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1828889989, G190135293, G1940663492, G2353495307, National institute for Neurological Research, Reducing speech-related side-effects of deep brain stimulation in Parkinson's Disease via automated speech analysis, REducing SPEECH-related side-effects of deep brain stimulation in Parkinson's disease via automated speech analysis (RESPEECH-PD), G622239581
OpenAlex ID: W4402574505