Year: 2024
Type: article
Abstract: The emergence of cellular immunotherapy treatments is introducing more efficient strategies to combat cancer as well as autoimmune and infectious diseases. However, the cellular manufacturing procedures associated with these therapies remain costly and time-consuming, thus limiting their applicability. Recently, lymph-node-inspired PEG-heparin hydrogels have been demonstrated to improve primary human T cell culture at the laboratory scale. To go one step further in their clinical applicability, we assessed their scalability, which was successfully achieved by 3D printing. Thus, we were able to improve primary human T cell infiltration in the biohybrid PEG-heparin hydrogels, as well as increase nutrient, waste, and gas transport, resulting in higher primary human T cell proliferation rates while maintaining the phenotype. Thus, we moved one step further toward meeting the requirements needed to improve the manufacture of the cellular products used in cellular immunotherapies.
Institutions: Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine, Centro de Investigación Biomédica en Red, Institut de Ciència de Materials de Barcelona, Barcelona Institute of Science and Technology, Institute for Bioengineering of Catalonia, Universitat Politècnica de Catalunya, Consejo Superior de Investigaciones Científicas, Universitat Internacional de Catalunya
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: Ministerio de Ciencia, Innovación y Universidades, European Commission, Generalitat de Catalunya, Ministerio de Economía y Competitividad, Max-Planck-Gesellschaft, Ministerio de Ciencia e Innovación, Horizon 2020 Framework Programme, Instituto de Salud Carlos III, European Regional Development Fund, H2020 Marie Skłodowska-Curie Actions
Awards: G1002662725, G114353912, G1150029139, G1926891744, G1953887145, G2010697503, G219249554, G2402982190, G2778265472, G2785476245, G2851561925, G2986824255, G327489216, G3345895242, G3367465167, G3690828678, G3743529912, G4133780255, G434337789, G4638889601, G4937468798, DOCtoral training programme in Functional Advanced Materials, G5175525644, G5257603219, G5462406284, G5756342936, G5805502524, G5845768719, G5976643093, DOCtoral training programme in Functional Advanced Materials, G6313766199, G6390037881, G6651449163, G6938418927, G7425137858, G7667914644, G7672670073, G7703859073, G7704543894, G7818575025, G7967443488, G8168323983, G8490104479, G8512683158, G8824911526, G996136629
OpenAlex ID: W4402574615