Work

Clinico-pathological association of BCL2 in invasive breast carcinoma: A study from tertiary care health centre in Northern India

Year: 2024

Type: article

Abstract: BACKGROUND: B-cell lymphoma 2 (Bcl-2) is an antiapoptotic protein and an important clinical breast cancer prognostic marker. The aim of this study was to evaluate the relationship between the BCL2 expression and clinico-pathological parameters in breast cancer. MATERIALS AND METHODS: Present study is observational cross-sectional study of 100 biopsy proven cases of breast cancer, and cases with resection specimens were included. IHC analyses for ER, PR, Her2neu, Ki67 and Bcl2 were performed in each case. RESULTS: Bcl2 expression was seen in 52% cases. BCL2-positive expression was associated with lower histological grade (0.026), low Ki-67 level (<14%, P < 0.001), hormone receptor positivity ( P < 0.001) and luminal breast cancer ( P < 0.001) but no association with tumour size, lymphovascular invasion, perineural invasion and TNM stage. CONCLUSION: Expression of Bcl-2, an antiapoptotic protein, is associated with low-grade, slowly proliferating, luminal A-type BC. IHC analysis of Bcl-2 is simple, inexpensive, readily available test to stratify early-stage hormone-positive patients who can be included in clinical trials for Bcl-2 inhibitors.

Source: Indian Journal of Pathology and Microbiology

DOI: 10.4103/ijpm.ijpm_259_24

Authors: Sarjana Tiwari, Kanwalpreet Kaur

Institutions: Max Super Speciality Hospital, Jawaharlal Institute of Post Graduate Medical Education and Research

Language: English

Topic: Breast Cancer Treatment Studies

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $200