A new tetrahydroxybenzophenone from a marine-associated fungus of penicillium sp. and its potential antibacterial activity
Year: 2024
Type: article
Abstract: Penicillium species are renowned for their ability to produce a wide range of secondary metabolites with medicinal properties. In this study, compounds 1-10 were isolated from Penicillium sp. Z-16, of which compound 1 is a new benzophenone derivative named methyl 2-(2,6-dihydroxy-4-methylbenzoyl)-4,5-dihydroxy-3-methoxybenzoate. The chemical structure of 1 was determined through comprehensive spectroscopic analysis, including 1D, 2D NMR (HMBC, HSQC) and HRESIMS. In addition, six other known compounds (11-16) were isolated and identified from Penicillium sp. T-5-1. The antimicrobial activity tests demonstrated that compound 1 was moderately active against Candida albicans with a MIC value of 125 μg/mL, while compound 2 showed a MIC value of 62.5 μg/mL against Staphylococcus aureus.
Source: Natural Product Research
Authors: Ruifeng Huang, Shuaiqi Ma, Jiale Wu, Asma Riaz, Li Song, Shaofen Zhou, Runhong Zhou, Jingnan Qiu, Jian He
Institution: Southern Medical University
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G6254218183, G7107761918
OpenAlex ID: W4402580658